Yonsei Institute for Advanced Study

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Research Areas

Magnetogenetics-Brain Computer Interface (MG-BCI)

We have developed magnetic nanoparticle-based magnetogenetic approaches for wireless, selective neuromodulation in vivo. Our work focuses on using magnetic nanoparticles as tools to stimulate neuronally expressed ion channels, enabling controlled modulation of neural activity while concurrently recording neural signals. By integrating magnetogenetics with brain computer interfaces that link neural signal readout to magnetic field driven stimulation in a closed loop framework, we aim to establish a powerful framework for the precise, scalable manipulation of complex neural circuits in vivo. This approach supports adaptive modulation based on real time neural dynamics beyond open loop neuromodulation. To achieve this, we are developing technologies that bridge magnetogenetics and BCI, including multiplexed magnetomechanical nanosystems, electrophysiological platforms optimized for magnetogenetic stimulation, and split protein-based ion channel delivery strategies.