Yonsei Advanced Science Institute

• Research Areas
• Research Highlights
• Publications

Research Areas

Multiplexed Magnetogenetics

We have developed a multiplexed magnetomechanical nanosystem designed to remotely and selectively modulate neural circuits using engineered magnetic nanoparticle assemblies. By fine-tuning the magnetic moment and anisotropy of each nanoparticle, we control their responses to different magnetic field strengths and stimulation patterns. This control leverages nanoscale magnetic behaviors—including Brownian rotation and Néel spin inversion—to induce torque on the particles. As a result, individual nanoparticles can be programmed with unique magnetic “signatures,” enabling the simultaneous and differential activation of multiple neural populations. This platform offers a powerful strategy for the precise and scalable manipulation of complex neural networks in vivo.

Electrophysiology for Magnetogenetic Systems

Electrophysiology is a core technique for analyzing the electrical signals that govern communication within neural circuits. We combine electrophysiological recording with magnetomechanical stimulation to study how mechanosensitive ion channels respond to magnetic torque in real time. This integration enables direct assessment of channel activation and neuronal excitability in response to remote, noninvasive magnetic inputs. Our approach provides critical insight into the fundamental biophysical mechanisms underlying magnetogenetic control and lays the groundwork for expanding this system to a wide range of mechanosensitive ion channels. Through this method, we aim to develop innovative neuromodulation tools with therapeutic potential for neurological disorders.

Sonogenetics

We explore the use of ultrasound as a noninvasive and selective modality for modulating neural activity in vivo. Our research focuses on uncovering the molecular, cellular, and physical mechanisms by which ultrasound interacts with neural tissues. A key part of this work involves studying the mechanosensitive ion channel Piezo1, which we use as a biological actuator to examine how focused ultrasound (FUS) influences motor behaviors in mice. By improving the precision, spatiotemporal resolution, and safety of ultrasound-based stimulation, our goal is to develop effective tools for both fundamental neuroscience research and clinical neuromodulation. These insights pave the way for future therapeutic applications targeting a broad range of brain disorders.