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[Precision Nanomedicine] Yoonhee Jin, Jung Seung Lee, Jin Kim, Sungjin Min, Soohyun Wi, Ji Hea Yu, Gyeong-Eon Chang, Ann-Na Cho, Yeeun Choi, Da-Hee Ahn, Sung-Rae Cho, Eunji Cheong, Yun-Gon Kim, Hyong-Pyo Kim, Yonghwan Kim, Dong Seok Kim, Hyun Woo Kim, Zhejiu Quan, Hoon-Chul Kang* & Seung-Woo Cho*
"Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons"
Nat. Biomed. Eng., 2, 522-539
 (Jul 11, 2018)
  DOI : https://www.nature.com/articles/s41551-018-0260-8

Biophysical cues can improve the direct reprogramming of fibroblasts into neurons that can be used f...

[Precision Nanomedicine] Ramu Gopalappa, Bharathi Suresh, Suresh Ramakrishna*, Hyongbum (Henry) Kim*
"Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruption"
Nucleic Acids Res., 46 (12), e71
 (Jul 6, 2018)
  DOI : https://academic.oup.com/nar/article/46/12/e71/4951847

The use of paired Cas9 nickases instead of Cas9 nuclease drastically reduces off-target effects. Bec...

[Precision Nanomedicine] Yoonhee Jin, Jin Kim, Jung Seung Lee, Sungjin Min, Suran Kim, Da‐Hee Ahn, Yun‐Gon Kim, Seung‐Woo Cho*
Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver‐Specific Microenvironment as a Drug Testing Platform
Adv. Funct. Mater., 28 (37), 1801954
 (Jun 26, 2018)
  DOI : https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201801954

Induced hepatic (iHep) cells generated by direct reprogramming have been proposed as cell sources fo...

[Precision Nanomedicine] Jae Hyo Han, Minkyoung Kwak, Youngsoo Kim, and Jinwoo Cheon*
Recent Advances in the Solution-Based Preparation of Two-Dimensional layered Transition Metal Chalcogenide Nanostructures
Chem. Rev.​, 118 (13), 6151-6188
 (Jun 21, 2018)
  DOI : https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00264

The precise control in size/thickness, composition, crystal phases, doping, defects, and surface pro...

[Nanobio Interface] Polina Anikeeva, Charles M. Lieber, and Jinwoo Cheon
Creating Functional Interfaces with Biological Circuits
Acc. Chem. Res., 51 (5), 987
 (May 15, 2018)
  DOI : https://pubs.acs.org/doi/10.1021/acs.accounts.8b00167

Guest Editorial for the Accounts of Chemical Research special issue on “The Interface of Biology with Nanoscience and Electronics”.

[Nanobio Interface] Ji-wook Kim, Hee-kyung Jeong, Kaden M. Southard, Young-wook Jun, and Jinwoo Cheon
Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time
Acc. Chem. Res., 51 (4), 839-849
 (Mar 28, 2018)
  DOI : https://pubs.acs.org/doi/abs/10.1021/acs.accounts.8b00004

Published as part of the Accounts of Chemical Research special issue “The Interface of Biology with Nanoscience and Electronics”

[Precision Nanomedicine] Seokhwan Yun, Tae-Hyun Shin, Jae-Hyun Lee , Mi Hyeon Cho , Il-Sun Kim, Ji-wook Kim, Kwangsoo Jung, Il-Shin Lee, Jinwoo Cheon*, and Kook In Park*
Design of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation
Nano Lett., 18 (2), 838-845
 (Feb 2, 2018)
  DOI : https://pubs.acs.org/doi/10.1021/acs.nanolett.7b04089

Magnetic nanoparticles, magnetic targeting, stem cell delivery, differentiation, cell therapy

[Precision Nanomedicine] Hui Kwon Kim, Seonwoo Min, Myungjae Song, Soobin Jung, Jae Woo Choi, Younggwang Kim, Sangeun Lee, Sungroh Yoon* and Hyongbum (Henry) Kim*
Deep learning improves prediction of CRISPR–Cpf1 guide RNA activity
Nat. Biotechnol., 36 (3), 239-241
 (Jan 29, 2018)
  DOI : https://www.nature.com/articles/nbt.4061#f1

We present two algorithms to predict the activity of AsCpf1 guide RNAs. Indel frequencies for 15,000...

[Precision Nanomedicine] Wonjoo Kim, Sangeun Lee, Han Sang Kim, Minjung Song, Yong Hoon Cha, Young-Hoon Kim, Jeonghong Shin, Eun-Seo Lee, Yeonsoo Joo, Jae J. Song, Eun Ju Choi, Jae W. Choi, Jinu Lee, Moonkyung Kang, Jong In Yook, Min Goo Lee, Yeon-Soo Kim, Soonmyung Paik, and Hyongbum (Henry) Kim*
Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth
Genome Res., 28, 374-382
 (Jan 11, 2018)
  DOI : https://genome.cshlp.org/content/28/3/374.full

KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent...

[Precision Nanomedicine] Jung Ho Cho, Jung Seung Lee, Jisoo Shin, Eun Je Jeon, Soohwan An, Yi Sun Choi, Seung‐Woo Cho*
Ascidian‐Inspired Fast‐Forming Hydrogel System for Versatile Biomedical Applications: Pyrogallol Chemistry for Dual Modes of Crosslinking Mechanism
Adv. Funct. Mater., 28 (6), 1705244
 (Dec 15, 2017)
  DOI : https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201705244

ascidians, drug delivery, fast gelation, hydrogels, pyrogallol, tissue engineering

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