Yonsei Advanced Science Institute

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Research Highlights

• [Precision Nanomedicine]   Mar 8, 2021
  High-Resolution T1 MRI via Renally Clearable Dextran Nanoparticles with an Iron Oxide Shell
  Tae-Hyun Shin†, Pan Ki Kim†, Sunghwi Kang, Jiyong Cheong, Soojin Kim, Yongjun Lim, Wookjin Shin, Joon-Yong Jung, Jungsu D. Lah, Byoung Wook Choi*, and Jinwoo Cheon* († equally contributed)
  Nat. Biomed. Eng., 5 (3), 252-263

  Contrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owi...

• [Precision Nanomedicine]   Jan 28, 2021
  Non-Contact Long-Range Magnetic Stimulation of Mechanosensitive Ion Channels in Freely Moving Animals
  Jung-uk Lee, Wookjin Shin, Yongjun Lim, Jungsil Kim, Woon Ryoung Kim, Heehun Kim, Jae-Hyun Lee, and Jinwoo Cheon*
  Nat. Mater., 20 (7), 1029–1036

  Among physical stimulation modalities, magnetism has clear advantages, such as deep penetration and ...

• [Precision Nanomedicine]   Dec 3, 2020
  Fast Detection of SARS-CoV-2 RNA via the Integration of Plasmonic Thermocycling and Fluorescence Detection in a Portable Device
  Jiyong Cheong†, Hojeong Yu†, Chang Yeol Lee, Jung-uk Lee, Hyun-jung Choi, Jae-Hyun Lee*, Hakho Lee*, and Jinwoo Cheon* († equally contributed)
  Nat. Biomed. Eng., 4, 1159–1167

  The diagnosis of severe acute respiratory syndrome 2 (SARS-CoV-2) infection by quantitative PCR with...

• [Nanobio Interface]   Oct 22, 2019
  Mechanoluminescent, Air-Dielectric MoS2 Transistors as Active-Matrix Pressure Sensors for Wide Detection Ranges from Footsteps to Cellular Motions
  Jiuk Jang†, Hyobeom Kim†, Sangyoon Ji, Ha Jun Kim, Min Soo Kang, Tae Soo Kim, Jong-eun Won, Jae-Hyun Lee, Jinwoo Cheon*, Kibum Kang*, Won Bin Im*, and Jang-Ung Park* († equally contributed)
  Nano Lett., 20 (1), 66-74

  Tactile pressure sensors as flexible bioelectronic devices have been regarded as the key component f...

• [Precision Nanomedicine]   Aug 28, 2019
  Magnetic Control of Axon Navigation in Reprogrammed Neurons
  Yoonhee Jin†, Jung-uk Lee†, Eunna Chung, Kisuk Yang, Jin Kim, Ji-wook Kim, Jong Seung Lee, Ann-Na Cho, Taekyu Oh, Jae-Hyun Lee, Seung-Woo Cho*, and Jinwoo Cheon* († equally contributed)
  Nano Lett., 19 (9), 6517-6523

  While neural cell transplantation represents a promising therapy for neurodegenerative diseases, the...

• [Nanobio Interface]   Apr 30, 2019
  Small, Clickable, and Monovalent Magnetofluorescent Nanoparticles Enable Mechanogenetic Regulation of Receptors in a Crowded Live-Cell Microenvironment
  Minsuk Kwak†, Wonji Gu†, Heekyung Jeong, Hyunjung Lee, Jung-uk Lee, Minji An, Yong Ho Kim, Jae-Hyun Lee, Jinwoo Cheon*, and Young-wook Jun* († equally contributed)
  Nano Lett., 19 (6), 3761-3769

  Multifunctional magnetic nanoparticles have shown great promise as next-generation imaging and pertu...

• [Evolutionary Nanomaterials]   Oct 11, 2018
  Activation of the Basal Plane in Two Dimensional Transition Metal Chalcogenide Nanostructures
  Jae Hyo Han†, Hong Ki Kim†, Bongkwan Baek, Jeonghee Han, Hyun S. Ahn, Mu-Hyun Baik*, and Jinwoo Cheon* († equally contributed)
  J. Am. Chem. Soc., 140 (42), 13663-13671

  Achieving a molecular level understanding of chemical reactions on the surface of solid-stat...

• [Precision Nanomedicine]   Jul 11, 2018
  Three-Dimensional Brain-Like Microenvironments Facilitate the Direct Reprogramming of Fibroblasts into Therapeutic Neurons
  Yoonhee Jin†, Jung Seung Lee†, Jin Kim, Sungjin Min, Soohyun Wi, Ji Hea Yu, Gyeong-Eon Chang, Ann-Na Cho, Yeeun Choi, Da-Hee Ahn, Sung-Rae Cho, Eunji Cheong, Yun-Gon Kim, Hyong-Pyo Kim, Yonghwan Kim, Dong Seok Kim, Hyun Woo Kim, Zhejiu Quan, Hoon-Chul Kang*, and Seung-Woo Cho* († equally contributed)
  Nat. Biomed. Eng., 2, 522-539

  Biophysical cues can improve the direct reprogramming of fibroblasts into neurons that can be used f...

• [Precision Nanomedicine]   Jan 29, 2018
  Deep Learning Improves Prediction of CRISPR–Cpf1 Guide RNA Activity
  Hui Kwon Kim†, Seonwoo Min†, Myungjae Song, Soobin Jung, Jae Woo Choi, Younggwang Kim, Sangeun Lee, Sungroh Yoon*, and Hyongbum (Henry) Kim* († equally contributed)
  Nat. Biotechnol., 36 (3), 239-241

  We present two algorithms to predict the activity of AsCpf1 guide RNAs. Indel frequencies for 15,000...

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