Yonsei Advanced Science Institute

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    • Biomedical Engineering
    • Minsuk Kwak (곽민석)
    • minsuk.kwak(at)yonsei.ac.kr


  • 2014 - 2017Ph.D. Biomedical Engineering, Yale University, CT, USA
  • 2011 - 2014M.S. Biomedical Engineering, Yale University, CT, USA
  • 2007 - 2011B.S. Bioengineering, Rice University, TX, USA

Professional Career

  • 2020 - PresentAssistant Professor, Nano Biomedical Engineering, Advanced Science Institute, Yonsei University, Seoul, Korea
  • 2017 - 2020Postdoctoral Fellow, Life Science Research Foundation, UCSF, CA, USA

Awards and Honors

  • 2019Best Poster Award, ACS Publication & IBS Forum: Nanomaterials for Energy and Life Sciences
  • 2018 - 2021Life Science Research Foundation (LSRF) Postdoctoral Research Fellowship
  • 2018 - 2020American Association of Cancer Research (AACR) Lymphoma Research Postdoctoral Fellowship (declined)
  • 2018 - 2019Burroughs Wellcome Fund 2018 Collaborative Research Travel Award
  • 2015 - 2016Edward L. Barlow Fellowship, Department of Biomedical Engineering, Graduate School Tuition and Support, Yale University,
  • 2007 - 2011Allen International Fellowship, Rice University, 4-year full university tuition and fee scholarship


15. Kwak M#, Southard KM#, Kim WR, Gopalappa R, Kim NH, Lee HJ, Seo D, Kim HB, Kim YH, Cheon J, Gartner Z*, Jun YW* (# equal Contribution), “Size-dependent protein segregation creates a spatial switch for Notch and APP signaling”, bioRxiv, https://doi.org/10.1101/2020.06.28.176560, 2020

14.Thach, T. T., Bae, D. H., Kim, N. H., Kang, E. S., Lee, B. S., Han, K., Kwak, M., Choi, H., Nam, J., Bae, T., Suh, M., Hur, J. K., Kim, Y. H., “Lipopeptide‐Based Nanosome‐Mediated Delivery of Hyperaccurate CRISPR/Cas9 Ribonucleoprotein for Gene Editing”. Small, 15, 1903172, 2019

13. Kwak M#, Gu W#, Jeong H, Lee HJ, Lee JU, An M, Kim YH, Lee JH, Cheon J, Jun YW, “Small, clickable, and monovalent magnetofluorescent nanoparticles (MFNs) enable mechanogenetic regulation of receptors in a crowded live cell microenvironment”, Nano Letters, 19(6): 3761-3769, 2019

12.Janiszewska M, Tabassum DP, Castano Z, Cristea S, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Alcazar CGD, Aleckovic M, Ekram MB, Cohen O, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A, Wucherpfennig KW, Wagle N, Fan R, Michor F, McAllister SS, Polyak K, “Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments”, Nature Cell Biology, 21, 879–888, 2019

11.Wang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucia J, Lu YC, Roden C, Cheng J, Krauss D, Ding Y, Fan R, Lu J, “Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms”, Nature Communication, 10(1): 95, 2018

10.Huh SJ, Alcazar CR, Ekram MB, Trinh A, Liu LL, Beca F, Zi X, Kwak M, Bergholtz H, Su Y, Ding L, Russnes HG, Richardson AL, Babski K, Kim EMH, McDonnell III CH, Wagner J, Rowberry R, Freeman GJ, Deborah Dillon D, Sorlie T, Coussens LM, Garber JE, Bobolis K, Allred DC, Park SY, Fan R, Michor F, and Polyak K, “Immune escape in breast cancer during in situ to invasive carcinoma transition”, Cancer Discovery, 7(10):1098-1115, 2017

9.Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju JA, Kim HJ, Lee JSH, Wu PH, Fan R, Gilkes DM, Wirtz D, “Novel synergistic IL6/8 paracrine signaling pathway infers new strategy to inhibit tumor cell migration”, Nature Communications. 8, 15584, 2017

8. Chen JJ, Kwak M, Fan R, “Single-cell cytokine profiling to investigate cellular functional diversity in hematopoietic malignancies”, Methods in Molecular Biology, 1465:243-54, 2016

7. Kwak M#, Han L#, Chen JJ, Fan R (# equal Contribution), “Interfacing Inorganic Nanowire Arrays and Living Cells for Cellular Function Analysis”, Small, 11(42), 5600-10, 2015

6. Kleppe M#, Kwak M#, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, McKenney AS, Papalexi E, Abdel-Wahab O, Rampal R, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Teruya-Feldstein J, Murakami M, Radimerski T, Michor F, Fan R*, Levine RL* (# first author), “JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response”, Cancer Discovery, 5(3): 316-313, 2015

5. Mao L, Shen L, Chen J, Wu Y, Kwak M, Lu Y, Xue Q, Pei J, Zhang L, Yuan G, Fan R, Ge J, Ding W, “Enhanced Bioactivity of Mg-Nd-Zn-Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application”, ACS Applied Material and Interfaces, 7(9): 5320-5330, 2015

4. Kwak M, Kim DJ, Lee MR, Wu Y, Han L, Lee SK, Fan R, “Nanowire Array Chips for Molecular Typing of Rare Trafficking Leukocytes with Application to Neurodegenerative Pathology”, Nanoscale, 6(12):6537-50, 2014

3. Lee SK, Kim DJ, Lee GH, Kim GS, Kwak M, Fan R, “Specific Rare Cell Capture Using Micro-patterned Silicon Nanowire Platform”, Biosensors and Bioelectronics, 54: 181-188, 2014

2. Kwak M, Mu L, Lu Y, Chen JJ, Brower K, Fan R, “Single-cell Protein Secretomic Signatures as Potential Correlates to Tumor Cell Lineage Evolution and Cell-cell Interaction”, Frontiers in Oncology, 3(10), 2013

1. Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R, “Nanowire Substrate-based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells”, Nano Letters, 12(6): 2697-2704, 2012



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