Yonsei Advanced Science Institute

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Faculty & SAB

    • Biomedical Engineering, Single-cell Imaging/Sequencing
    • Chang Ho Sohn (손창호)
    • chsohn(at)yonsei.ac.kr


  • 2006 - 2011Ph.D. Chemistry, California Institute of Technology, CA, USA
  • 2000 - 2006B.S. Chemistry, Seoul National University, Seoul, Korea (military service: 2002-2004)

Professional Career

  • 2020 - PresentAssistant Professor, Nano Biomedical Engineering, Advanced Science Institute, Yonsei University, Seoul, Korea
  • 2017 - 2019Postdoctoral Fellow/Research Scientist, Institute of Medical Engineering and Science, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, MA, USA
  • 2011 - 2017Postdoctoral Scholar/Staff Scientist, Division of Chemistry and Chemical Engineering, California Institute of Technology, CA, USA

Awards and Honors

  • 2010Graduate student travel award, American Society for Mass Spectrometry.
  • 2006 - 2011Kwanjeong Educational Foundation, S. Korea, Graduate Fellowship for study abroad
  • 2006Highest honor graduate, Seoul National University, S. Korea
  • 2005 - 2006Yuhan Educational Foundation, S. Korea, Undergraduate Fellowship
  • 2004Lotte Foundation, S. Korea, Undergraduate Fellowship
  • 2000 - 2001Seoul National University, S. Korea, GPA-based Scholarship



1. Chang Ho Sohn, … J. L. Beauchamp*, JACS2009, 131, 5444-5459.

2. Chang Ho Sohn, … J. L. Beauchamp*, JACS, 2012, 134, 2672-2680 

3. Chang Ho Sohn, Heather D. Agnew, … J. L. Beauchamp*, Anal. Chem. 2012, 84, 2662-2669co-1st.

4. Chang Ho Sohn, … J. L. Beauchamp*, Chem. Sci., 2015, 6, 4550-4560.

5. Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai, and Michael B. Elowitz*, Nature, 2015, 527, 54-58.

6. Young-Gyun ParkChang Ho Sohn, Ritchie Chen, … Kwanghun Chung*, Nat. Biotechnol., 2019, 37, 73-83. co-1st authors. Cover article.

7. Yandong ZhangChang Ho Sohn, … Long Cai*, Commun. Biol. 2020, 3, 420. co-1st authors.



16. AlexandreAlbanese, Justin M. Swaney, Dae HeeYun, Nicholas B. Evans, Jenna M.Antonucci , SilviaVelasco, Chang Ho Sohn, PaolaArlotta, LeeGehrke & Kwanghun Chung, Multiscale 3D phenotyping of human cerebral organoids, Scientific reports. 2020 , 10, 21487.

15. Yandong ZhangChang Ho Sohn, Seoyeon Lee, Heejeong Ahn, Jinyoung Seo, Junyue Cao, and Long Cai, Detecting protein and post-translational modifications in single cells with iDentification and qUantification sEparaTion (DUET), Commun. Biol. 2020, 3, 420. co-1st authors.

14. Dae Hee Yun, Young-Gyun Park, Jae Hun Cho, Lee Kamentsky, Nicholas Evans, Alexandre Albanese, Katherine Xie, Justin Swaney, Chang Ho Sohn, Yuxuan Tian, Qiangge Zhang, Gabrielle Drummond, Webster Guan, Nicholas DiNapoli, Heejin Choi, Hae-Yoon Jung, Luzdary Ruelas, Guoping Feng, and Kwanghun Chung, Ultrafast immunostaining of organ-scale tissues for scalable proteomic phenotyping, under review. co-1st authors.

13. Taeyun Ku, Webster Guan, Nicholas B. Evans, Chang Ho Sohn, Alexandre Albanese, Matthew P. Frosch, and Kwanghun Chung, Elasticizing tissues for reversible shape transformation and accelerated molecular labeling, Nat. Methods2020, 17, 609-613.

12. Young-Gyun ParkChang Ho Sohn, Ritchie Chen, Margaret McCue, Dae Hee Yun, Gabrielle T. Drummond, Taeyun Ku, Nicholas B. Evans, Hayeon Caitlyn Oak, Wendy Trieu, Heejin Choi, Xin Jin, Varoth Lilascharoen, Ji Wang, Matthias C. Truttmann, Helena W. Qi, Hidde L. Ploegh, Todd R. Golub, Shih-Chi Chen, Matthew P. Frosch, Heather J. Kulik, Byung Kook Lim, Kwanghun Chung, Protection of tissue physicochemical properties using polyfunctional crosslinkers, Nat. Biotechnol., 2019, 37, 73-83. co-1st authors. Cover article.

11. Sowmya Chandrasekar, Michael J. Sweredoski, Chang Ho Sohn, Sonja Hess and Shu-ou Shan, Co-evolution of two GTPases enables efficient protein targeting in an RNA-less chloroplast Signal Recognition Particle pathway, J. Biol. Chem., 2017, 292, 386-396.

10. Sheel Shah, Eric Lubeck, Maayan Schwarzkopf, Ting-Fang He, Alon GreenbaumChang Ho Sohn, Antti Lignell, Harry Choi, Viviana Gradinaru*, Niles Pierce*, and Long Cai*, Single-molecule RNA detection at depth via hybridization chain reaction and tissue hydrogel embedding and clearing, Development, 2016, 143, 2862-2867. co-1st authors, *co-corresponding authors.

9. Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai, and Michael B. Elowitz, Combinatorial gene regulation by modulation of relative pulse timing, Nature, 2015, 527, 54-58.

8. Chang Ho Sohn, Sheng Yin, Ivory Peng, Joseph A. Loo and J. L. Beauchamp, Investigation of the mechanism of electron capture and electron transfer dissociation of peptides with a covalently attached free radical hydrogen atom scavenger, Int. J. Mass Specrom.2015, 390, 49-55.

7. Chang Ho Sohn, Jinshan Gao, Daniel A. Thomas, Tae-Young Kim, William A. Goddard III and J. L. Beauchamp, Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry, Chem. Sci., 2015, 6, 4550-4560.

6. Daniel A. Thomas, Chang Ho Sohn, and J. L. Beauchamp, Hydrogen bonding constrains free radical reaction dynamics at serine and threonine residues in peptides, J. Phys. Chem. A 2014, 118, 8380-8392

5. Paul J. Minor, Ting-Fang He, Chang Ho Sohn, Anand R. Asthagiri, Paul W. SternbergFGF signaling upregulates Wnt in C. elegans vulval cell lineage polarityDevelopment 2013, 140, 3882-3891.

4. Jinshan Gao, Daniel A. Thomas, Chang Ho Sohn, and J. L. Beauchamp, Biomimetic reagents for selective free radical and acid-base chemistry of glycans: application to glycan structure determination by mass spectrometry, J. Am. Chem. Soc. 2013, 135, 10684-10692.

3. Chang Ho Sohn, Heather D. Agnew, Geoffrey T. Smith, Michael J. Sweredoski, Robert L. Graham, Sonja Hess, Gregg Czerwieniec, Joseph A. Loo, Raymond J. Deshaies, James R. Heath and J. L. Beauchamp, Designer reagents for mass spectrometry-based proteomics: clickable cross-linker for elucidation of protein structures and interactions, Anal. Chem. 2012, 84, 2662-2669co-1st authors. (featured in C&EN News)

2. Chang Ho Sohn, J. Eugene Lee, Geoffrey T. Smith, Michael J. Sweredoski, Robert L. Graham, Sonja Hess, Gregg Czerwieniec, Joseph A. Loo, Raymond J. Deshaies and J. L. Beauchamp, Click chemistry facilitates formation of reporter ions and synthesis of amine-reactive multiplexed isobaric tags for protein quantification, J. Am. Chem. Soc., 2012, 134, 2672-2680 

1. Chang Ho Sohn, Cheol K. Chung, Sheng Yin, Prasanna Ramachandran, Joseph A. Loo and J. L. Beauchamp, Probing the mechanism of electron capture and electron transfer dissociation using tags with variable electron affinity, J. Am. Chem. Soc.2009, 131, 5444-5459. (featured in Analytical Chemistry)


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