Yonsei-IBS Professor Jinwoo Cheon's Joint Research Team with
the University of California, San Francisco Developed Nanotechnology that Determines Cell-Fate
-Future prospects are that it can suppress cancer metastasis and improve nerve cells
-Research results presented in prestigious biotechnology journal Cell
Humans are not the only ones that can communicate and make negotiations. Cells are also capable of communicating signals. This is made possible through biomolecules. Then would it be possible to make adjustments to cell-to-cell communication so that it could meet our needs?
To solve this question, research teams of Yonsei University and UC San Francisco conducted a joint research. By integrating nanotechnology and gene technology, they devised ¡°mechano-genetics.¡± Research teams led by Professor Jeon Young Wook(UCSF, visiting professor of Yonsei-IBS center for nanomedicine), Professor Z. Gartner(UCSF) and Professor Jinwoo Cheon(Yonsei-IBS) published their findings in the prestigious biotechnology journal ¡°Cell.¡± They developed technology that enables cell-to-cell communication on a single molecule level.
Mechano-genetics controls neural-transmissions by using magnetic nano-particles to stimulate the communication molecules on the surface of cells. The stimulus amounts to Pico newton-level mechanical force. That is, mechano-genetics is about nano-particles causing structural changes in communication molecules within cells and ultimately activating cells.
With this very technology, the international joint research team succeeded in unearthing how typical organic communication molecules such as Notch- and E-cadherin-mechanoreceptors work on cell surfaces. Furthermore, this case provided a promising outlook that humans can control the activation of cells anywhere at any time, even on a single molecule level.
It is highly likely that mechano-genetics nanotechnology would contribute to and be applied to various fields, from life science to medical science. Notch- and E-cadherin-mechanoreceptors, for instance, are critical proteins that are associated with an organism¡¯s growth and differentiation as well as activation of immune cells and cancer metastasis.
Meanwhile, Y-IBS Center for Nanomedicine strives to explore vital phenomena based on nanotechnology and aims to establish a brand new scheme in the medical science field of studies.
Y-IBS holds an international symposium in commemoration of
the founding of Yonsei University
Y-IBS has hosted an international symposium discussing ¡°Breakthroughs of Quantum Dots for the Future.¡± It took place at the Helinox Hall located in Yonsei University, May 23rd.
About 70 participants attended the symposium. Celebrating Yonsei University¡¯s 131st anniversary, world-famous nanotechnology scientists, including Dr. Benoit Dubertret of the French National Science Research Center, Dr. B. Murray of Pennsylvania State University, and Dr. Daniel Gamelin of Washington University, were invited to discuss future prospects of nanomaterial and nanomedicine.
The Yonsei- IBS center for nanomedicine was founded in December, 2015. The center explores vital phenomena based on nanotechnology. It ultimately aims to establish new concepts and platforms for future medical science.