Professor Yoon Tae Young¡¯s lab, which belongs to the Yonsei-Institute of Basic Science, proved that inositol 7-phosphate is a powerful key to controlling communication among neurons through synaptotagmin.
This research was jointly conducted under the lead of Professor Yoon¡¯s research team, Professor Kim Se Yoon¡¯s research team of the department of life science in KAIST, and Professor Kim Seong Hyun¡¯s research team of Kyunghee Medical School. This research project incorporated interdisciplinary fields of studies from neurobiology to super resolution optical imaging. Its study results were published in the June 30th edition of Proceedings of the National Academy of Sciences of the United States of America, a prestigious science journal.
Inositol polyphosphate metabolome is an essential compound for the human body. It is usually found in cereals and beans.
Among inositol polyphostate metabolomes, inositol 6-phostate has anticancer properties and plays a crucial role in the cellular signaling system.
Inositol 7-phosphate was first discovered 20 years ago. It has constantly been proved to play a critical role in forming diabetes and obesity.
When the human body has inadequate inositol polyphosphate metabolome, it is known to cause mental disorders and neurodegenerative diseases. However, a clear-cut explanation of the roles inositol 7-phosphate play among neurons and neural-transmission is not addressed yet.
Professor Yoon¡¯s research team has accumulated unrivaled technical skills through conducting years of research, reenacting neural-transmission outside the human cells. Professor Kim Se Yoon¡¯s research team has also proved that even a small amount of inositol 7-phosphate can be a powerful controlling substance for cell signaling. Both research teams were the very first to observe that synthesized inositol 7-phosphate is dozens of times more efficient when it comes to restraining neural-transmissions. Most importantly, they proved that inositol 7-phosphate represses synaptotagmin, one of the core proteins for neural-transmission, hindering neuron-to-neuron communication.
Professor Kim Seong Hyun¡¯s research team of Kyunghee University also observed inositol 7-phosphate hindering neuron-to-neuron communication in hippocampal neurons. The joint research team hereby substantiated that inositol polyphostate metabolomes are the key to neural-transmission in the brain.
This research project holds great significance in that it was conducted successfully under joint research teams and required various fields of professional scientific technology. These study results are expected to contribute to further research on neurological disorders. The fact that synaptotagmin and inositol 7-phosphate are closely interrelated will help research teams reveal the mechanism of neural-transmission.